Dragon's Dogma Online! I don't know if anyone's actually hyped for this game or anything, but it looks like they made it so that it could possibly make it overseas.
I noticed that it detected what keyboard layout I was using and modified its controls to match, and I know European keyboard formats are different than the ones typical in Japan or North America. Normally, you'd be using WASD to walk around, and that usually throws me for a loop, especially if I can't change them. But, I noticed I was walking around just fine using my WARS keys (the Colemak equivalent). Sometimes the key help text corresponds to what's on my keyboard, sometimes it doesn't, but it's remapped no matter what it says.
You can't change the basic keys on DDO... which I think is horrible and they need to add it, but somehow it's less of a big deal for me now.